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Counting initial cell and animal studies, and regulatory review at the end, the process easily Adidas Superstar Olive Cargo takes a decade and more than $1 billion. But for rare diseases, the drugs are tested on much smaller groups, sometimes just a few hundred or few dozen. And patient testing can wrap up a couple of years sooner. That, plus government financial incentives, can cut development costs by o. Adidas Superstar Blue Shoes
already sell for $100,000 or more for a year of treatment, although drugmakers usually give financial aid to patients and big discounts to insurers and government health programs. "They're recreating the blockbuster," said analyst Steve Brozak of WBB Securities. "There's more money, fewer patients Adidas Superstar Rose Gold Tip
and it's 10 times easier to defend high prices to payers. "Last year, the Food and Drug Administration approved a record 17 medicines for rare diseases.
, starting a decade ago, patents on some of the industry's most lucrative medicines began to expire, and cheap generic drugs started wiping out tens of billions of dollars in annual revenue. So many companies shifted money to rare disease drugs, knowing that those medicines cost less to develop and will face limited competition. Some Adidas Superstar Pink
More than 450 others are in development to treat a wide variety of ailments rare cancers, sickle cell disease, the hormonal disorder Cushing's disease and a bleeding ailment called thrombocytopenic purpura, as well as hemophilia, Hodgkin's lymphoma and pulmonary fibrosis. Patient advocacy groups are getting better at raising money for research and building registries of patients that could be used to recruit participants for drug studies, a process that otherwise can take years. In the 1970s, only a handful of rare disease drugs got approved. Then the 1983 Orphan Drug Act helped rouse interest by providing expedited drug reviews, tax credits and other benefits for drug companies. For diabetes, heart and other common medications, drugmakers must test treatments on thousands of patients, usually through three rounds of studies lasting roughly seven years total.